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 Presentation

"Adipocyte-Derived Factors: Effects on Insulin Sensitivity and Cardiovascular Disease"

Prof. Philipp Scherer (biography)
English - 2006-12-06 - 54 minutes
(48 slides)

Summary :
Adipocyte-derived factors are known to have an impact on various processes, including inflammation, angiogenesis, and energy homeostasis, among others.

Adiponectin is a well-studied adipocyte-derived factor shown to have potent anti-atherosclerotic properties, and a number of studies have looked at circulating adiponectin levels and the risk of future cardiovascular disease. High adiponectin levels have been associated with lower risk of myocardial infarction in men, for example (1). The ratio of high molecular weight adiponectin to total adiponectin, in particular, has been found to be useful for predicting the presence of insulin resistance and metabolic syndrome (2). Also of interest is that improvement in hepatic insulin-sensitivity as an effect of peroxisome proliferator-activated receptor gamma (PPARγ) activation by glitazones, appears to be positively correlated with levels of high molecular weight adiponectin (3). More recently, adiponectin has also been found in human cerebrospinal fluid (4).

Animal studies provide insights into the mechanisms of action of adiponectin, and the impact of adipose tissue on systemic physiology. Prof. Scherer discusses studies in mice with transgenic overexpression of adiponectin and in mice with inducible fat loss, and finally, some in vitro data on the impact of hyperglycemia on adipocytes.

Copyright © 2007 MULTIWEBCAST "State-of-the-Art Webcast Services"

Learning objectives :
- Adipocyte-derived factors and their major physiological impact
- Appreciate the systemic contributions of adipose tissue to inflammation
- Understand the contribution of adiponectin towards glucose homeostasis
- Understand the epidemiological correlations between CVD and adiponectin

Bibliographic references :
1. Tobias Pischon, MD, MPH; Cynthia J. Girman, DrPH; Gokhan S. Hotamisligil, MD, PhD; Nader Rifai, PhD; Frank B. Hu, MD, PhD; Eric B. Rimm, ScD Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men JAMA. 2004;291:1730-1737.

2. Hara K, Horikoshi M, Yamauchi T, Yago H, Miyazaki O, Ebinuma H, Imai Y, Nagai R, Kadowaki T.Measurement of the High–Molecular Weight Form of Adiponectin in Plasma Is Useful for the Prediction of Insulin Resistance and Metabolic Syndrome Diabetes Care. 2006;29:1357-1362.

3. Tonelli J, Li W, Kishore P, Pajvani UB, Kwon E, Weaver C, Scherer PE, Hawkins M.Mechanisms of Early Insulin-Sensitizing Effects of Thiazolidinediones in Type 2 Diabetes Diabetes 53:1621-1629, 2004.

4. Kusminski CM, McTernan PG, Schraw T, Kos K, O'hare JP, Ahima R, Kumar S, Scherer
PE.Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution
from serum.
Diabetologia. 2007 Mar;50(3):634-42.

   


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