Insulin Resistance presentations about Insulin Resistance EB with interest for Insulin Resistance Validating Insulin Resistance content Free registration form / enregistrement gratuit
1
2
  Franšais - August 16, 2011
Welcome to the #1 online source of information for Diabetes Specialists! An international online community of more than 10,000 Diabetes Specialists.

CME on Diabetes is a website built to transmit top-level CME conferences given by international experts in endocrinology, insulin resistance, prediabetes, metabolic syndrome and type 2 diabetes. More than 2.6 million slides have been viewed since the website launch. Thank you for your continued support and commitment!
 Presentation

"Are Free Fatty Acids the Link between Obesity, Insulin Resistance, Endothelial Dysfunction and Atherosclerosis?"

Dr. Guenther Boden (biography)
English - 2003-08-28 - 49 minutes
(31 slides)
(1 question)

Summary :
Recorded during the 18th IDF Meeting, Paris: We are now learning more about the role of elevated FFAs in insulin resistance. Fatty acids are necessary within the muscle cell to an extent, as a source of fuel for the mitochondria, but elevated fatty acids can cause insulin resistance as we will see here. When fatty acids enter the cell, they get activated to long form Acyl-CoA and then esterified to triglyceride, but along the way diacylglycerol (DAG) gets formed. This activates PKC which phosphorylates IRS-1 thereby destroying IRS-1 and disrupting the insulin signaling chain. Here we take a look at this chain of events and see how it interconnects with the development of conditions such as inflammation, endothelial dysfunction and atherosclerosis.

Learning objectives :
The participant will learn the mechanism whereby plasma FFAs enter the muscle cell and cause insulin resistance, and how this affects the development of atherosclerosis, inflammation and endothelial dysfunction.

Bibliographic references :
Boden G.Effects of Free Fatty Acids (FFA) on Glucose Metabolism: Significance for Insulin Resistance and Type 2 Diabetes.

Boden G, Cheung P, Mozzoli M, Fried SK.Effect of thiazolidinediones on glucose and fatty acid metabolism in patients with type 2 diabetes.

   


  Login
  Username :
  Password :
   
  Lost your password?


  Search our website
  Would you like to know more about insulin resistance? Are you looking for information pertaining to Type 2 Diabetes? You can find what you are looking for in over 2000 references available on CMEonDiabetes.
 

  Social
  Let others know about this presentation.

 Del.icio.us
 Digg!



MULTILEARNING - MULTIWEBCAST - MULTIEPOSTER - MULTIEPORTAL

Copyright © 2002-2015 MULTILEARNING Group INC.. All rights reserved.  Disclaimer
Powered by Multiwebcast - webcast services


USER ACKNOWLEDGES AND AGREES THAT ALL DECISIONS MADE WITH THE ASSISTANCE OR USE OF THE SOFTWARE AND/OR THE WEBSITE AND/OR BASED ON CONTENT FOUND HEREIN WILL BE EXCLUSIVELY THE RESPONSIBILITY OF THE USER.
insulin resistanceC-Reactive Protein (CRP)CRP, C-Reactive ProteinADHD ADDdiabetes insulin