Insulin Resistance presentations about Insulin Resistance EB with interest for Insulin Resistance Validating Insulin Resistance content Free registration form / enregistrement gratuit
1
2
  Franšais - August 16, 2011
Welcome to the #1 online source of information for Diabetes Specialists! An international online community of more than 10,000 Diabetes Specialists.

CME on Diabetes is a website built to transmit top-level CME conferences given by international experts in endocrinology, insulin resistance, prediabetes, metabolic syndrome and type 2 diabetes. More than 2.6 million slides have been viewed since the website launch. Thank you for your continued support and commitment!
 Presentation

"Beta Cell Apoptosis and Diabetes"

Dr. Minna Woo (biography)
English - 2002-04-26 - 30 minutes
(29 slides)

Summary :
Insulin resistance and beta cell failure are the major culprits that contribute to development of diabetes mellitus. Over the last decade, much focus has been on the insulin resistance in the diabetes research arena. However, recently, insulin-producing beta cells have received attention in diabetes mellitus. Both animal and human data support the evidence of beta cell failure as a contributing factor in type 2 diabetes mellitus. Beta cell apoptosis has been shown to play a role in this process.

Apoptosis is an evolutionarily conserved cellular process that is essential in many aspects of normal development and disease. A broad overview of apoptosis will be discussed. I will show the genetic evidence to support our current model, particularly highlighting the knockout mice data. Physiologic and pathologic beta cell apoptosis will be outlined, including the neonatal wave of islet apoptosis and its implications particularly in Type 1 diabetes mellitus. In Type 1 diabetes mellitus, beta cell apoptosis may play a role in diabetes development in two distinct phases of the disease. First, developmental wave of islet apoptosis may affect the T-cell biology that ultimately impact on the onset of autoimmune diabetes. Secondly, islet apoptosis is also the mode of cell death that finally result in the massive destruction of beta cells. Much of our knowledge in the apoptotic mechanisms of beta cells in Type 1 diabetes mellitus can be applied in diabetes mellitus research.

Learning objectives :
The participant will learn about beta cell apoptosis: it's genetic foundations, physiologic and pathologic characteristics; and how it may contribute to diabetes types 1 and 2.


Bibliographic references :
Executionary pathway for apoptosis: lessons from mutant mice.

Woo M, Hakem R, Mak TW.

Amgen Institute and Ontario Cancer Institute, Department of Immunology, University of Toronto, Canada. mwoo@oci.utoronto.ca

Apoptosis or programmed cell death (PCD) is an evolutionarily conserved cellular process that is essential for normal development and homeostasis of multicellular organisms. Defects in the apoptosis signaling result in many diseases including autoimmune diseases and cancer. The apoptosis signaling pathway was first described genetically in the nematode Caenorhabditis elegans which serves as a framework for the more complex apoptotic pathways that exist in mammals. In this review, we will discuss the apoptotic pathways that are emerging in mammals as elucidated by studies of gene-targeted mutant mice.

Cell Res 2000 Dec;10(4):267-78


   


  Login
  Username :
  Password :
   
  Lost your password?


  Search our website
  Would you like to know more about insulin resistance? Are you looking for information pertaining to Type 2 Diabetes? You can find what you are looking for in over 2000 references available on CMEonDiabetes.
 

  Social
  Let others know about this presentation.

 Del.icio.us
 Digg!



MULTILEARNING - MULTIWEBCAST - MULTIEPOSTER - MULTIEPORTAL

Copyright © 2002-2015 MULTILEARNING Group INC.. All rights reserved.  Disclaimer
Powered by Multiwebcast - webcast services


USER ACKNOWLEDGES AND AGREES THAT ALL DECISIONS MADE WITH THE ASSISTANCE OR USE OF THE SOFTWARE AND/OR THE WEBSITE AND/OR BASED ON CONTENT FOUND HEREIN WILL BE EXCLUSIVELY THE RESPONSIBILITY OF THE USER.
insulin resistanceC-Reactive Protein (CRP)CRP, C-Reactive ProteinADHD ADDdiabetes insulin