Insulin Resistance presentations about Insulin Resistance EB with interest for Insulin Resistance Validating Insulin Resistance content Free registration form / enregistrement gratuit
1
2
  Franšais - August 16, 2011
Welcome to the #1 online source of information for Diabetes Specialists! An international online community of more than 10,000 Diabetes Specialists.

CME on Diabetes is a website built to transmit top-level CME conferences given by international experts in endocrinology, insulin resistance, prediabetes, metabolic syndrome and type 2 diabetes. More than 2.6 million slides have been viewed since the website launch. Thank you for your continued support and commitment!
 Presentation

"Insulin Resistance Is A Risk Factor For Cardiovascular Disease: YES"

Dr. Ehud Ur (biography)
English - 2002-04-27 - 43 minutes
(27 slides)
(30 slides)

Summary :
It is estimated that by year 2020 there will be approximately 250 million people affected by type 2 diabetes (DM2) worldwide. In Canada, the current prevalence is expected to double by that date. Although the underlying cause of diabetes is unknown, it is clear that insulin resistance (IR) plays a major role in the development and progression of the disease. Whilst IR can be seen as a molecular phenomenon involving defective insulin signaling, it also needs to be understood as a biochemical abnormality driving cardiovascular disease (CVD) both within and outside the context of overt DM2. The evidence for such an association comes from both epidemiological and pathophysiological data. With the advent of drugs that directly target IR, we are also beginning to accumulate pharmacotherapeutic data that support the central role of IR in the development of atherosclerosis.


Learning objectives :
The participant will learn why insulin resistance is a risk factor for CVD, based on pathophysiology and epidemiological findings.


Bibliographic references :
Relationship between obesity, insulin resistance, and coronary heart disease risk.

Abbasi F, Brown BW Jr, Lamendola C, McLaughlin T, Reaven GM.

Department of Medicine, Stanford, California, USA

OBJECTIVES: The study goals were to: 1) define the relationship between body mass index (BMI) and insulin resistance in 314 nondiabetic, normotensive, healthy volunteers; and 2) determine the relationship between each of these two variables and coronary heart disease (CHD) risk factors. BACKGROUND: The importance of obesity as a risk factor for type 2 diabetes and hypertension is well-recognized, but its role as a CHD risk factor in nondiabetic, normotensive individuals is less well established.
METHODS: Insulin resistance was quantified by determining the steady-state plasma glucose (SSPG) concentration during the last 30 min of a 180-min infusion of octreotide, glucose, and insulin. In addition, nine CHD risk factors: age, systolic blood pressure, diastolic blood pressure (DBP), total cholesterol, triglycerides (TG), high-density lipoprotein (HDL) cholesterol and low-density lipoprotein cholesterol concentrations, and glucose and insulin responses to a 75-g oral glucose load were measured in the volunteers. RESULTS: The BMI and the SSPG concentration were significantly related (r = 0.465, p < 0.001). The BMI and SSPG were both independently associated with each of the nine risk factors. In multiple regression analysis, SSPG concentration added modest to substantial power to BMI with regard to the prediction of DBP, HDL cholesterol and TG concentrations, and the glucose and insulin responses.
CONCLUSIONS: Obesity and insulin resistance are both powerful predictors of CHD risk, and insulin resistance at any given degree of obesity accentuates the risk of CHD and type 2 diabetes.

J Am Coll Cardiol 2002 Sep 4;40(5):937-43


   


  Login
  Username :
  Password :
   
  Lost your password?


  Search our website
  Would you like to know more about insulin resistance? Are you looking for information pertaining to Type 2 Diabetes? You can find what you are looking for in over 2000 references available on CMEonDiabetes.
 

  Social
  Let others know about this presentation.

 Del.icio.us
 Digg!



MULTILEARNING - MULTIWEBCAST - MULTIEPOSTER - MULTIEPORTAL

Copyright © 2002-2015 MULTILEARNING Group INC.. All rights reserved.  Disclaimer
Powered by Multiwebcast - webcast services


USER ACKNOWLEDGES AND AGREES THAT ALL DECISIONS MADE WITH THE ASSISTANCE OR USE OF THE SOFTWARE AND/OR THE WEBSITE AND/OR BASED ON CONTENT FOUND HEREIN WILL BE EXCLUSIVELY THE RESPONSIBILITY OF THE USER.
insulin resistanceC-Reactive Protein (CRP)CRP, C-Reactive ProteinADHD ADDdiabetes insulin