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- March 10, 2010 |
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| Presentation |
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"The Clinical Implications of Advanced Glycation"Dr. Merlin C. Thomas (biography)
English - 2006-09-13 - 43 minutes
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 | (62 slides) |
Summary :
In this presentation Dr. Merlin Thomas of the Baker Heart Research Institute talks about the relevance of advanced glycation in diabetic patients. A number of haemodynamic and metabolic factors operate in chronic hyperglycemia, says Dr. Thomas, however, one pivotal pathway appears to be the formation and accumulation of advanced glycation end-products (AGEs).
AGEs are formed by the non-enzymatic reaction between reducing sugars and the amino groups on proteins, lipids or nucleic acids, and have a wide range of chemical, cellular and tissue activities implicated in the development and progression of diabetic complications (1,2).
There is strong experimental evidence that AGEs have physiologically relevant actions in vivo, but what about in the diabetic patient? Here Dr. Thomas gives a detailed description of ten reasons why AGEs are important in the clinic.
Copyright © 2006 E-MedHosting.com Inc.
Learning objectives :
After viewing this presentation the participant will be able to discuss:
- What are AGEs?
- Experimental evidence for AGEs as downstream mediators of hyperglycemic injury
- Ten reasons why AGEs are important in the clinic
Bibliographic references :
1. Josephine M. Forbes, Mark E. Cooper, Matthew D. Oldfield and Merlin C. Thomas Role of Advanced Glycation End Products in Diabetic Nephropathy J Am Soc Nephrol 14:S254-S258, 2003.
2. Helen Vlassara. The AGE-receptor in the pathogenesis of diabetic complications Diabetes/Metabolism Research and Reviews. Volume 17, Issue 6 , Pages 436 - 443.
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